Semantic dementia, progressive non-fluent aphasia and their association with amyotrophic lateral sclerosis

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چکیده

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Semantic dementia, progressive non-fluent aphasia and their association with amyotrophic lateral sclerosis

INTRODUCTION The association between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is well recognised, with the majority of reports describing the behavioural form of FTD (bvFTD). Semantic dementia (SD) and progressive non-fluent aphasia (PNFA) have only rarely been reported alongside ALS. Nevertheless, there have been a number of recent reports of language abnormalities...

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Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy.

We report five patients with a stereotyped clinical syndrome characterized by fluent dysphasia with severe anomia, reduced vocabulary and prominent impairment of single-word comprehension, progressing to a stage of virtually complete dissolution of the semantic components of language. A marked reduction in the ability to generate exemplars from restricted semantic categories (e.g. animals, vehi...

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Progressive hemiparesis (Mills syndrome) with aphasia in amyotrophic lateral sclerosis

The onset of motor symptoms in amyotrophic lateral sclerosis (ALS) is strikingly focal. In three-quarters of cases, weakness emerges unilaterally in one limb, typically spreading contiguously over months to become bilateral.(1) An extremely rare clinical syndrome of upper motor neuron-predominant, progressive hemiparesis was first described by American neurologist Charles Karsner Mills (1845-19...

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Verbal and non-verbal semantic impairment: From fluent primary progressive aphasia to semantic dementia

Selective disturbances of semantic memory have attracted the interest of many investigators and the question of the existence of single or multiple semantic systems remains a very controversial theme in the literature. Objectives To discuss the question of multiple semantic systems based on a longitudinal study of a patient who presented semantic dementia from fluent primary progressive aphas...

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Repeat and Point: differentiating semantic dementia from progressive non-fluent aphasia.

To determine whether a new, simple, quick measure, the Repeat and Point test, reliably differentiates between semantic dementia (SD) and progressive non-fluent aphasia (PNFA). Fifteen patients with SD, six patients with PNFA and 18 healthy controls were administered the Repeat and Point test. Participants were required to repeat 10 multi-syllabic concrete nouns and, following each repetition, t...

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ژورنال

عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry

سال: 2017

ISSN: 0022-3050,1468-330X

DOI: 10.1136/jnnp-2016-314912